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Active Healing

The Unique Biological Solution for Active Healing

COMBO is more than just a drug-eluting stent (DES). It is a combination of traditional DES components with the addition of a biological coating

 

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Function of the Biological Coating

CD34 antibodies are immobilized on the surface of the stent and capture circulating endothelial progenitor cells (EPCs). The captured EPCs are triggered by sheer stress from the circulating blood and other cell signals to differentiate and mature into endothelial cells. COMBO Plus is the only stent with a biological coating that actively repairs the vessel morphology.

 

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Features and Benefits

The Unique Biological Solution for Active Healing

COMBO is more than just a drug-eluting stent (DES). It is a combination of traditional DES components with the addition of a biological coating.

Sirolimus Release from a Bioabsorbable Polymer

The proprietary bioabsorbable polymer is coated on the abluminal side of the stent, allowing for directional drug release in 30 days and polymer absorption in 90 days. 

Dual Helix Stent Design

COMBO’s dual helix design is engineered for:

  •   Excellent radial strength
  •   Large side branch access
  •   Natural conformability

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    Key clinical findings

    Unique 24-Month Neointimal Regression

    A mechanistic study demonstrated that repeat OCT follow-up in the same patients showed a significant decrease in neointimal thickness and volume at 24-month compared to 9-month follow-up, indicative of neointimal maturation and stability.



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S. Lee et al. The EGO-COMBO study. Circ .Cardiovasc Interv.2016;9e0034609

Low Event Rates demonstrate Safe Results

Studies have consistently shown low event rates. In the REMEDEE Registry (N=1000), 1-year results in an all comers' population showed effectiveness with low target lesion revascularization, and safety with low rates of cardiac death, myocardial infarction and stent thrombosis

 

 

 

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P. Woudstra et al. 1-Yea Results of the REMEDEE Registry. J Am Coll Cardiol Intv 2016;9:1127-34

 

Technical Specifications

 

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Ordering Information

 

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Download EMEA PDF

Download APAC PDF

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Contact US


54 Ibn Zareeq Street , Sport City,

P.O Box 960377 Amman 11196
Jordan,

Tel : +962 6 5154826 
Fax : +962 6 5154825

Email : info@hijazibros.com

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